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The von hippel—lindau vhl disease is an autosomal dominant syndrome, first reported in the twentieth century, characterized by the predisposition for multiple tumors caused by mutations in the vhl gene .

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In this prospective, non-randomised, single-centre, single-arm, open-label, phase 2 study, we assessed patients with genetically confirmed von hippel-lindau disease or clinical features and family history consistent with von hippel-lindau disease who were having surveillance for at least one measurable von hippel-lindau disease-related lesion.

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